Translational Control in Oocyte Development

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Translational control in oocyte development.

Translational control of specific mRNAs is a widespread mechanism of gene regulation, and it is especially important in pattern formation in the oocytes of organisms in which the embryonic axes are established maternally. Drosophila and Xenopus have been especially valuable in elucidating the relevant molecular mechanisms. Here, we comprehensively review what is known about translational contro...

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Translational control during early development

In eukaryotic cells, specific sets of proteins associate with genome DNA and mRNA to package them into nucleosomes and mRNPs, respectively. Among the crucial functions of these DNAor RNA-protein complexes are to protect the nucleic acids incorporated into the complexes from attack by nucleases, to package them into compact particles and, most importantly, to regulate gene expression through com...

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Translational control in germline stem cell development

Stem cells give rise to tissues and organs during development and maintain their integrity during adulthood. They have the potential to self-renew or differentiate at each division. To ensure proper organ growth and homeostasis, self-renewal versus differentiation decisions need to be tightly controlled. Systematic genetic studies in Drosophila melanogaster are revealing extensive regulatory ne...

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The translational control phase of early development.

The giant unicellular alga, Acetabularia, can develop a complex f ru i t i ng body in the absence of a nucleus (H~immerling~ 1963), a process which can be regulated wholly by translational control (Harr is , 1968; Brachet~ 1968). Exactly analogous independence of nuclear act ivi ty is found in the development of animals. Take the frog's egg as an example. In the ovary the oocyte is stimulated b...

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ژورنال

عنوان ژورنال: Cold Spring Harbor Perspectives in Biology

سال: 2011

ISSN: 1943-0264

DOI: 10.1101/cshperspect.a002758